IndraLab

Statements



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"STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer."

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"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."

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"Therefore, we investigated whether STAMBPL1 promotes tumor angiogenesis."

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"In this study, we discovered that STAMBPL1 promotes angiogenesis in TNBC by activating the HIF1α/VEGFA pathway independently of its enzymatic activity."

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"STAMBPL1 in TNBC cells enhances the activity of HUVECs and promotes TNBC angiogenesis."

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"Knocking down STAMBPL1 inhibited the growth of HCC1806 xenografts in mice (Figure 3G–I) and decreased the number of microvessels in tumor tissue (Figure 3J, K), indicating that STAMBPL1 promoted tumor angiogenesis."