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USP19 activates RING1. 2 / 2

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"In addition, USP19 antagonizes ring finger protein 1 (RPF1)-mediated malic enzyme 1 (ME1) degradation through deubiquitination, which in turn promotes lipid metabolism associated with ERK2 activity and CRC development in human patients [139]."

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"Ubiquitin-specific peptidase 19 (USP19) antagonizes ring finger protein 1 (RNF1)-mediated ME1 degradation by deubiquitination, thereby promoting lipid metabolism and NADPH production, and suppressing ROS, thereby promoting colorectal carcinogenesis [141]."

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USP19 activates RING1. 2 / 2

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