IndraLab

Statements

STAMBP inhibits EGFR. 5 / 8
| 5
reach
"Short interfering RNA (siRNA) knockdown of AMSH accelerates EGFR down-regulation."
15314065
reach
"In contrast, EGF-R internalization is inhibited by AMSH protein."
16925951
reach
"Inhibition of AMSH accelerates EGFR down-regulation suggesting a role in antagonizing ubiquitin dependent sorting of cargo to the lysosome."
19489724
reach
"Depletion of AMSH, which alters the balance of E3 ligase and DUB activity in the endosomal system, enhances the degradation of EGFR, presumably by inhibiting the removal of ubiquitin from EGFR and thereby preventing its ability to recycle."
24456136
reach
"Conversely, AMSH negatively regulates EGFR down-regulation and is proposed to recycle the EGFR at the sorting endosome."
16702236