IndraLab

Statements

STAMBP inhibits EGFR. 6 / 9
| 6
reach
"In contrast, EGF-R internalization is inhibited by AMSH protein."
16925951
reach
"Based on siRNA-depletion experiments, AMSH is proposed to negatively regulate EGFR downregulation and consequently to enhance recycling of the receptor ( Bowers et al., 2006 ; McCullough et al., 2004 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22975321
reach
"Depletion of AMSH, which alters the balance of E3 ligase and DUB activity in the endosomal system, enhances the degradation of EGFR, presumably by inhibiting the removal of ubiquitin from EGFR and thereby preventing its ability to recycle."
24456136
reach
"Inhibition of AMSH accelerates EGFR down-regulation suggesting a role in antagonizing ubiquitin dependent sorting of cargo to the lysosome."
19489724
reach
"Conversely, AMSH negatively regulates EGFR down-regulation and is proposed to recycle the EGFR at the sorting endosome."
16702236
reach
"Short interfering RNA (siRNA) knockdown of AMSH accelerates EGFR down-regulation."
15314065