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"To substantiate the in vivo stabilization of HIF-1alpha by HAUSP, a transient co-transfection experiment showed that overexpression of HAUSP increased HIF-1alpha at the protein levels but not the mRNA levels (XREF_FIG and XREF_SUPPLEMENTARY), and further activated a Twist1 promoter driven reporter construct (XREF_FIG) XREF_BIBR."