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USP15 activates ptc. 10 / 10
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"Furthermore, the knockdown of USP15 could also reduce the migration and invasion capacity of PTC cells as evaluated by transwell invasion assays (Figures 5C and 5D) (PTC cell VS Ctrl, P<0.001) and wound healing (Figures 5E and 5F) (PTC cell VS Ctrl, P<0.001), whereas this phenomenon was reversed in USP15 overexpressed B-CPAP cells (Figures 5G and 5H) (PTC cell VS Vector P<0.001)."
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"In the current study, our results found that MFSD4A-AS1 functioned as ceRNA to sequester miR-30c-2-3p, miR-145-3p and miR-139-5p to disrupt the miRNA-mediated inhibition of VEGFA and VEGFC on the one hand; on the other hand, MFSD4A-AS1 further activated TGF-β signaling by sponging miR-30c-2-3p to relieve the repressive effect of miR-30c-2-3p on TGFBR2 and USP15, which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC."
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"Mechanistic dissection further revealed that MFSD4A-AS1 functioned as competing endogenous RNA to sequester miR-30c-2-3p, miR-145-3p and miR-139-5p to disrupt the miRNA-mediated inhibition of vascular endothelial growth factors A and C, and further activated transforming growth factor (TGF)-beta signaling by sponging miR-30c-2-3p that targeted TGFBR2 and USP15, both of which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC."
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"It was not difficult to find that USP15 was a potent DUB responsible for HMGB1 and USP15 promoted PTC progression by K48-linked deubiquitinating and stabilizing HMGB1."
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"USP15 promotes PTC progression via HMGB1."
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"USP15 depletion significantly decreased cell proliferation rate (Figure 5A) (PTC cell VS Ctrl and Vector, P<0.001)."
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"USP15 depletion significantly decreased PTC cell proliferation, migration, and invasion."
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"In contrast, overexpression of USP15 promoted cell proliferation (Figure 5B) (PTC cell VS Ctrl and Vector, P<0.001)."
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"Taken together, these results indicated that USP15 promoted PTC progression through HMGB1."
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"Recently, a study indicated that MFSD4A-AS1 activated transforming growth factor (TGF)-β signaling by sponging miR-30c-2-3p that targeted TGFBR2 and USP15, which promoted lymphangiogenesis and lymphatic metastasis of PTC 31."
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