IndraLab

Statements

EGFR phosphorylates USP8 on Y717. 5 / 5
1 | 2 2
reach
"Here, we report that epidermal growth factor receptor (EGFR) kinase suppresses ciliogenesis by directly phosphorylating the deubiquitinase USP8 on Tyr 717 and Tyr 810 in RPE1 cells."
29472535
sparser
"USP8 phosphorylation on Tyr717 and Tyr810 by EGFR kinase elevates its activity and then activates an inhibitory mechanism of ciliogenesis, i.e., EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase [ xref ]."
32512887
biopax:phosphositeplus
No evidence text available
sparser
"Additionally, EGFR kinase-induced phosphorylation of USP8 at Tyr717 and Tyr810 residues elevates its activity and activates the EGF receptor kinase-mediated inhibition of ciliogenesis."
34177595
reach
"KD of the EGF receptor (EGFR) in human RPE cells inhibits USP8 Tyr717 and Tyr810 phosphorylation, which enables TCHP and AURKA degradation and reverses the serum-induced effects on ciliogenesis and cell proliferation [50]."
| PMC