IndraLab

Statements

L. erythrocarpa inhibits KCNH2. 8 / 8
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"These findings indicate that HERG channels are also greatly blocked by BuOH fraction of L. erythrocarpa while remaining at the holding potential."
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"We found that L. erythrocarpa blocked the HERG channel, resulting in a shift in voltage-dependence of channel activation and reduction of maximum conductance (g max)."
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"In conclusion, we have shown here that L. erythrocarpa blocks HERG channel, resulting in a shift of voltage-dependence of channel activation and reduction of g max, and that the H 2 O and BuOH fractions exhibits the strongest changes in V 1/2 and g max among the solvent fractions."
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"Voltage dependent HERG channel blockade by L. erythrocarpa."
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"These findings indicate that HERG channels are greatly blocked by H 2 O fraction of L. erythrocarpa at the holding potential."
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"Consistent results were that L. erythrocarpa blocks HERG channel at the holding potential rather than at the depolarizing pulse (XREF_FIG)."
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"Although it has not been reported that L. erythrocarpa prolongs the APD or induces cardiac arrhythmia to our knowledge, our results suggest that L. erythrocarpa blocks the HERG channel, a major component of the I Kr, which could make the heart prone to arrhythmia since I Kr is one of the targets for antiarrhythmic therapy and the blocking of this current is expected to increase the APD and thereby increase the refractory period."
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"Fraction dependent inhibition of HERG channels by L. erythrocarpa."
19949665