IndraLab

Statements

USP25 activates macropinocytosis. 4 / 4
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"USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer."
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"Indeed, USP21 expression restored macropinocytosis in Kras*-extinguished cells, and macropinocytosis inhibitors thwarted USP21-induced Kras* escape.Finally, to identify the direct target of USP21 activity, the investigators used the protein as bait to capture a single interacting culprit: MARK3, a microtubule-binding kinase and regulator of microtubule dynamics (Sandí et al. 2017)."
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"Furthermore, Hou et al. revealed that USP21 increases macropinocytosis by microtubule-affinity-regulating kinase 3 (MARK3), thus providing metabolic support after KRAS mutation extinction in PDAC cancer cells [51]."
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"This Outlook discusses the finding by Hou et al. describing the mechanism by which the deubiquitinase USP21 up-regulates the nutrient-scavenging process of macropinocytosis, rescuing PDAC cells from Kras extinction."
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