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ATXN3 deubiquitinates PRKN. 17 / 18
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"PolyQ expansion does not alter binding between ataxin-3 and parkin, however, it enhances ataxin-3's deubiquitination of parkin, particularly by cleaving K27- and K29-linked ubiquitin chains [89]."
38497605
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"With parkin, ataxin-3 was unable to remove individual Ub moieties or preformed Ub chains after they had formed, suggesting that ataxin-3 was deubiquitinating parkin through a more unconventional mechanism."
23653622
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"This evidence indicates that ataxin 3 reduces the ubiquitination of parkin, a regulatory protein of the mitophagy pathway through a novel ataxin 3/parkin/E2 enzyme mechanism.OTUB1 is confirmed to co-e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34023421
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"As with USP33 and USP8, the MJD-associated Ataxin-3 reduced the ubiquitination of Parkin by diverting the actively assembling ubiquitin molecules onto itself instead of onto Parkin, which was suggested to reduce activity and turnover of Parkin, but negatively affecting its function."
36831318
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"ATXN3 can prevent self-ubiquitination of PRKN, thereby modulating PRKN activity (Durcan et al., 2012)."
36926679
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"The ubiquitin E3 ligase parkin, a risk gene for familial PD, was shown to be deubiquitinated by ATXN3."
38612794
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"Ataxin-3 deubiquitinates parkin in cells and in recombinant in vitro systems, in a manner that involves its UIMs [89]."
38497605
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"ATXN3 deubiquitinates PARKIN directly and reduces the extent of PARKIN ubiquitination in cells [81]."
34160773
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"Interestingly, although ataxin-3 deubiquitinates parkin, parkin is unable to ubiquitinate ataxin-3."
23653622
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"Thus, it is likely that Ataxin-3 inhibits parkin autoubiquitination by intercepting the Ub from E2 ~ Ub with its own active site thiol and the resulting DUB thioester intermediate is protected from hydrolysis by the stable ternary complex."
23845989
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"Additionally, it was shown that Ataxin-3 decreased the degree of Parkin self-ubiquitination, which was dependent on the active site Cys14 of Ataxin-3 and was exacerbated by polyQ tract expansion."
36831318
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"Ataxin-3 is proposed to reduce this self ubiquitination of Parkin by removal of the isopeptide linkage [XREF_BIBR]."
24293103
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"In a later study by Durcan et al. [60] from 2012, it was shown that rather than deubiquitinating Parkin, Ataxin-3 hydrolyzed the ubiquitin conjugates while they were actively assembled but was unable to hydrolyze already formed chains."
36831318
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"However, ataxin-3 did not deubiquitinate PARKIN in a classical manner, as it was unable to hydrolyze the isopeptide linkage in PARKIN Ub conjugates after they had formed (Durcan et al. 2012)."
25995186
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"Recently, it has been shown that ataxin-3 deubiquitinates C-terminus of Hsp70 interacting protein (CHIP) and parkin XREF_BIBR, XREF_BIBR."
22970133
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"Ataxin-3, a DUB associated with Machado-Joseph disease, was reported to reduce the self ubiquitination of parkin, a familiar form of Parkinson disease associated E3 ubiquitin-ligase [XREF_BIBR]."
28031783
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"Wild-type and polyQ expanded ataxin-3 deubiquitinate parkin directly and parkin ubiquitinates and facilitates the clearance of wild-type and mutant ataxin-2 and ataxin-3 by proteasomal degradation [XREF_BIBR - XREF_BIBR]."
25309920