IndraLab
Statements
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"Interestingly, although ataxin-3 deubiquitinates parkin, parkin is unable to ubiquitinate ataxin-3."
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"With parkin, ataxin-3 was unable to remove individual Ub moieties or preformed Ub chains after they had formed, suggesting that ataxin-3 was deubiquitinating parkin through a more unconventional mechanism."
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"ATXN3 deubiquitinates PARKIN directly and reduces the extent of PARKIN ubiquitination in cells [81]."
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"Ataxin-3, a DUB associated with Machado-Joseph disease, was reported to reduce the self ubiquitination of parkin, a familiar form of Parkinson disease associated E3 ubiquitin-ligase [XREF_BIBR]."
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"Thus, it is likely that Ataxin-3 inhibits parkin autoubiquitination by intercepting the Ub from E2 ~ Ub with its own active site thiol and the resulting DUB thioester intermediate is protected from hydrolysis by the stable ternary complex."
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"Wild-type and polyQ expanded ataxin-3 deubiquitinate parkin directly and parkin ubiquitinates and facilitates the clearance of wild-type and mutant ataxin-2 and ataxin-3 by proteasomal degradation [XREF_BIBR - XREF_BIBR]."
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"Ataxin-3 is proposed to reduce this self ubiquitination of Parkin by removal of the isopeptide linkage [XREF_BIBR]."
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"Recently, it has been shown that ataxin-3 deubiquitinates C-terminus of Hsp70 interacting protein (CHIP) and parkin XREF_BIBR, XREF_BIBR."