IndraLab

Statements

BAP1 deubiquitinates Histone_H2A. 5 / 5
| 5
reach
"BRCA1-associated protein 1 (BAP1) [18], the crucial constituent of the deubiquitinase complex, attenuated the initiation and extension of SLC7A11 transcription by deubiquitinating histone 2A, while the steady-state levels and half-life of SLC7A11 were improved by combination with the ovarian tumor family member deubiquitinase (OTUB1) [19]."
32908642
reach
"BAP1 deubiquitinates histone 2A (H2Aub) on the SLC7A11 promoter and represses SLC7A11 expression in a p53-independent way (39, 40)."
39290692
reach
"The mechanism may be that BAP1 represses the transcription of SLC7A11 by reducing histone 2A ubiquitination (H2Aub) on the SLC7A11 gene (49)."
35434035
reach
"BAP1 deubiquitinates histone 2A in the regulatory chromatin of the of SLC7A11 gene, which encodes, a key transporter of extracellular cysteine."
33446574
reach
"Specially, previous studies demonstrate that BAP1 downregulates SLC7A11 expression by reducing histone 2A ubiquitination occupancy on its promoter (Zhang et al., 2018b)."
37250891