IndraLab

Statements

USP7 activates signal transduction. 8 / 8
| 1 7
reach
"Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway."
34812471
reach
"Therefore, USP7 stabilizes BCR-ABL and activates its signaling pathway and inhibition of USP7 activates the apoptotic signals in CML cells."
33963175
reach
"USP7 knockout restored MM sensitivity to BTZ and induced apoptosis by stabilizing IκBα and blocking the NF-κB signaling pathway."
33967786
reach
"USP7 activates the BCR-ABL signaling pathway."
33963175
reach
"The TME includes adipocytes [3, 134], and one study showed that the exo-circ-deubiquitination (exo-circ-DB) derived from adipocytes upregulated the expression levels of USP7 and Cyclin A2 by sponging miR-34a and activating the USP7/CyclinA2 signalling pathway, thereby promoting the tumorigenesis and metastasis of HCC [135]."
31973726
eidos
"Independently of its action on p53 , USP7 modulates various pathways in homeostasis or during oncogenesis by targeting a large panel of substrates involved in cell cycle , DNA damage response , immune response , signal transduction , neuronal differentiation , and epigenetic regulation [ 7 , 9 ] ."
32447346
reach
"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
30542736
reach
"Consistently, USP7 activates the BCR-ABL signaling pathway and markedly increases CML cell viability."
33963175