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USP7 activates signal transduction. 18 / 18
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"Moreover, we found that loss of USP7 suppressed the progression of OS via inhibiting NLRP3 inflammasome signaling pathway."
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"Moreover, USP7 siRNA blocked the activation of Akt/ERK signaling pathway."
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"It has been shown that USP7 mediates pathophysiological angiogenesis by regulating the Sp1/Sp3-Notch1 signaling pathway in response to angiotensin-converting enzyme inhibitor (ACEI) [11]."
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"Moreover, USP7 activates the canonical NF-κB signaling pathway in myeloma patients through MEK2 stabilization, which regulates the PP1α/AKT axis [74,75] (Figure 4)."
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"The TME includes adipocytes [3, 134], and one study showed that the exo-circ-deubiquitination (exo-circ-DB) derived from adipocytes upregulated the expression levels of USP7 and Cyclin A2 by sponging miR-34a and activating the USP7/CyclinA2 signalling pathway, thereby promoting the tumorigenesis and metastasis of HCC [135]."
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"Consistently, USP7 activates the BCR-ABL signaling pathway and markedly increases CML cell viability."
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"Conversely, overexpression of USP7 inhibited osteoclast differentiation but activated the STING signaling pathway (Fig. 4E)."
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"Interestingly, in the present study, USP7 activated the NF-κB signaling pathway."
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"USP7 activates the BCR-ABL signaling pathway."
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"Therefore, we hypothesized that USP7 may be involved in the regulation of airway mucus hypersecretion.3.3 USP7 activated NF-KB signaling pathway in the airway mucus hypersecretion model."
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"Therefore, USP7 stabilizes BCR-ABL and activates its signaling pathway and inhibition of USP7 activates the apoptotic signals in CML cells."
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"USP7 knockout restored MM sensitivity to BTZ and induced apoptosis by stabilizing IκBα and blocking the NF-κB signaling pathway."
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"Independently of its action on p53 , USP7 modulates various pathways in homeostasis or during oncogenesis by targeting a large panel of substrates involved in cell cycle , DNA damage response , immune response , signal transduction , neuronal differentiation , and epigenetic regulation [ 7 , 9 ] ."
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"Loss of USP7 suppressed the progression of OS via inhibiting NLRP3 inflammasome signaling pathway."
38467635
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"These findings suggest that USP7 stimulates the NF-kappaB signaling pathway, which promotes airway mucus hypersecretion."
38778971
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"These results indicate that the knockdown of USP7 inhibits the ERK1/2 signaling pathway via a p53-dependent mechanism."
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"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
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"USP7 stabilizes β-catenin through deubiquitination and activates the Wnt signalling pathway, whereas the β-catenin inhibitory domain of APC protects β-catenin from deubiquitination by USP7 (148)."
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