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USP4 deubiquitinates TP53. 3 / 3
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"In the cytosol, USP4 deubiquitinates the member of many vital cell signaling pathways, e.g., NF-κB [77], TGF-β [54], Wnt/β-catenin [78], and p53 [79] as well as adenosine A2A receptor [80] and the E3 ligase TRIM21 [81]."
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"USP4 is a deubiquitinating enzyme which may inhibit p53 by deubiquitinating an important p53 ubiquitin ligase ARF-BP1 [35]."
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"Regulation of <span class="match term1">p53</span> is also subject to other DUBs, such as <span class="match term0">USP4</span>, USP10, USP29, and <span class="match term0">USP4</span>2 [171]."
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