IndraLab

Statements

OTUB1 binds CCN6. 14 / 14
3 | 2 9
sparser
"Therefore, it is possible that OTUB1 interacts with CCN6 through its linker domain."
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sparser
"CCN6 was co‐precipitated from 4T1 cell lysates together with OTUB1 by anti‐OTUB1 antibody (Figure  xref ), suggesting an interaction between endogenous OTUB1 and CCN6."
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sparser
"Further study showed OTUB1 interacts with CCN6 and decreases CCN6 ubiquitination independent of its enzymatic activity ( xref )."
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sparser
"The role of OTUB1–CCN6 interaction in breast cancer was studied with cell experiments and the allograft model."
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sparser
"• OTUB1 interacts with CCN6 through the linker domain and stabilizes CCN6 protein by reducing K48 ubiquitination."
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sparser
"Collectively, this study identified a OTUB1–CCN6 signal axis that suppresses cancer cell proliferation and migration in advanced breast cancer."
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sparser
"OTUB1 directly interacted with CCN6 through its linker domain to reduce the K48 polyubiquitination and degradation of CCN6 in a non‐canonical way."
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reach
"Molecular docking was performed to predict the interaction between OTUB1 and CCN6."
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reach
"Co‐IP experiment showed that, although the truncated OTUB1 lacking the UBA domain interacted with CCN6, the truncated OTUB1 lacking both UBA and linker domains failed to bind CCN6, indicating that the linker domain is needed for the binding between OTUB1 and CCN6 (Figure 3E).3.4 OTUB1 stabilizes CCN6 through the non-canonical function."
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biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
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sparser
"OTUB1‐GFP, but not GFP, was detected in the immunocomplex, showing that CCN6 directly interacts with OTUB1 (Figure  xref )."
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sparser
"Molecular docking was performed to predict the interaction between OTUB1 and CCN6."
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