IndraLab

Statements

TNFAIP3 inhibits TRAF2. 5 / 5
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sparser
"Moreover we demonstrated that A20 could inhibit RIP- and TRAF2- but not NIK-induced NF-κB–dependent reporter gene activation, suggesting that A20 interferes with NF-κB activation upstream of NIK."
10385526
eidos
"A20 ( also known as TNFAIP3 ) , a protein that acts as a negative feedback regulator of NF-kappaB signaling54 , mediates TRAF2 degradation55 ."
35122056
sparser
"Since TRAF2 overexpression activates these signaling events via distinct downstream components [ xref ], a simple explanation of these observations is that A20 may directly inhibit TRAF2 to terminate these signals."
18952128
reach
"WT TNFAIP3 induces the degradation of TRAF2 in a dose dependent manner; whereas, the catalytic mutant C103A fails to do so (XREF_FIG)."
20483768
sparser
"The mechanism of A20-dependent TRAF2 inhibition is still unknown."
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