"Similarly, Nutlin-3 disrupts Mdm2–p73 binding in p53-deficient cells, resulting in increased transcription of the growth inhibitory or pro-apoptotic p73 responsive genes p21 , Noxa and Puma and a[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"Both mutant p53 and p73 bind MDM2, while p63 binds much more weakly."
"Treatment with Nutlin-3, which inhibits the interaction between MDM2 and p53 or p73, had no effect on the sensitivity and survival of 4T1 cells to 6-TG (data not shown) ."
"Examples of this include Hdmx that binds the disordered transcription activation domains of p53 and p73( xref ), c-Jun and c-Fos that function as part of the AP-1 complex among many others( xref )."
"In addition, small-molecule inhibitors such as Nutlin-3 and RETRA, which disrupt the interaction of p53 and p73 with MDM2, can efficiently block KSHV-induced cell proliferation and cancer progression, promoting apoptotic cell death [ xref , xref ]."
"These results indicate that although hMDM2 can interact with both p53 and p73, its inhibition of p73 transcriptional activity is not mediated by a mechanism involving p73 protein degradation."
"To seek the chemical compounds to efficiently block the KSHV-driven cell proliferation and its associated cancers, Gao and Schulz groups have shown that the small-molecule inhibitors Nutlin-3 and RETRA, which disrupt the interaction of p53 and p73 with MDM2, are efficient to individually induce apoptotic cell death in a p53 and p73-dependent manner ( xref ; xref )."
"Both p53 and p73 bind to mdm2, but only p53 is degraded through the activity of mdm2."
"We observed that the small-molecule inhibitor Nutlin-3, which disrupts the interaction of p53 and p73 with MDM2, induces apoptotic cell death in p53 wild-type, as well as p53-mutant PEL cell lines, suggesting a possible involvement of p73."
"We examine why MDM2 interacts preferentially with p53 and p73."
"Nutlin-3, a novel MDM2 inhibitor, has been shown to inhibit the p53-MDM2 or p73-MDM2 interaction, leading to the stabilization of p53 or p73 protein
[ xref , xref ]."
"These antibodies inhibit the interaction between either p53 or p73 and mdm2, and may be useful tools for the study of these proteins."
"Furthermore, our studies suggest that there exist specific spatial requirements for the interaction between p53 or p73 and mdm2."
"Since MDM2 interacts with both p53 and p73, it is likely that ARF can regulate the activity of both p53 and p73 through MDM2 but not through MDMX."
"Both mutant p53 and p73 bind MDM2 well, whereas p63 binds much more weakly."