IndraLab

Statements

TP53 binds TP73 and MDM2. 16 / 16
| 16
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"Similarly, Nutlin-3 disrupts Mdm2–p73 binding in p53-deficient cells, resulting in increased transcription of the growth inhibitory or pro-apoptotic p73 responsive genes p21 , Noxa and Puma and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19447627
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"Since MDM2 interacts with both p53 and p73, it is likely that ARF can regulate the activity of both p53 and p73 through MDM2 but not through MDMX."
11223036
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"In addition, small-molecule inhibitors such as Nutlin-3 and RETRA, which disrupt the interaction of p53 and p73 with MDM2, can efficiently block KSHV-induced cell proliferation and cancer progression, promoting apoptotic cell death [ xref , xref ]."
27258263
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"These results indicate that although hMDM2 can interact with both p53 and p73, its inhibition of p73 transcriptional activity is not mediated by a mechanism involving p73 protein degradation."
10562283
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"Both p53 and p73 bind to mdm2, but only p53 is degraded through the activity of mdm2."
11850851
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"We observed that the small-molecule inhibitor Nutlin-3, which disrupts the interaction of p53 and p73 with MDM2, induces apoptotic cell death in p53 wild-type, as well as p53-mutant PEL cell lines, suggesting a possible involvement of p73."
22964633
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"Nutlin-3, a novel MDM2 inhibitor, has been shown to inhibit the p53-MDM2 or p73-MDM2 interaction, leading to the stabilization of p53 or p73 protein [ xref , xref ]."
24884809
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"Intriguingly, when MDM2 is overexpressed in cells carrying mutp53, this complex is inhibited by MDM2, which switches to the formation of mutp53-TAp73-MDM2 complex, leading to furthermore enhanced resistance to cisplatin, etoposide, and doxorubicin in SkBr3 and H1299 cells expressing p53 R175H [ xref ]."
| PMC
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"Furthermore, our studies suggest that there exist specific spatial requirements for the interaction between p53 or p73 and mdm2."
11850851
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"Both mutant p53 and p73 bind MDM2, while p63 binds much more weakly."
25417702
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"To seek the chemical compounds to efficiently block the KSHV-driven cell proliferation and its associated cancers, Gao and Schulz groups have shown that the small-molecule inhibitors Nutlin-3 and RETRA, which disrupt the interaction of p53 and p73 with MDM2, are efficient to individually induce apoptotic cell death in a p53 and p73-dependent manner ( xref ; xref )."
27065950
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"We examine why MDM2 interacts preferentially with p53 and p73."
20158876
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"Both mutant p53 and p73 bind MDM2 well, whereas p63 binds much more weakly."
25417702
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"Treatment with Nutlin-3, which inhibits the interaction between MDM2 and p53 or p73, had no effect on the sensitivity and survival of 4T1 cells to 6-TG (data not shown) ."
27626309
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"Examples of this include Hdmx that binds the disordered transcription activation domains of p53 and p73( xref ), c-Jun and c-Fos that function as part of the AP-1 complex among many others( xref )."
23286197
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"These antibodies inhibit the interaction between either p53 or p73 and mdm2, and may be useful tools for the study of these proteins."
11850851