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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP9X inhibits cell migration. 3 / 4

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"Cell migration was notably inhibited in HepG2 and PC3 cells after knockdown of USP9X with shRNA, suggesting USP9X promotes cell migration (XREF_SUPPLEMENTARY)."

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"The depletion and pharmacological inhibition of USP9X by WP1130, an inhibitor of USP9X, downregulate endogenous Snail1 protein, inhibit cell migration, invasion, metastasis, and increase cellular sensitivity to cisplatin and paclitaxel both in vitro and in vivo, whereas the reconstitution of Snail1 in cells with USP9X depletion at least partially reverses these phenotypes."

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"Cell migration and invasion were significantly inhibited by down-regulation of USP9X."

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Statements

USP9X inhibits cell migration. 3 / 4

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