IndraLab

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"Given that CYLD is a well characterized NF-kappaB transcriptional target, and in keeping with results obtained from DLD1, HCT116 and COS7 cells (XREF_SUPPLEMENTARY), there are low expression levels of endogenous CYLD and contrary to RANKL stimulated conditions, CYLD could not be upregulated by MG132 that is largely due to the inhibitory effects of MG132 towards NF-kappaB signaling."