IndraLab

Statements


Cyclin activates USP28. 2 / 2
| 2

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"It had an important function in inhibition of NSCLC (non small cell lung cancer) development that was mediated by cyclin D1 and ubiquitin specific peptidase28 (USP28) which target miR-3940-5p (Sun et al. 2013, Ren et al. 2017)."

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"The non-amplified and cyclin E1 hi group had significantly increased USP28, while the amplified and cyclin E1 hi cancers had significantly lower FBXW7 expression consistent with a role for both in stabilizing cyclin E1."