IndraLab

Statements

USP4 inhibits inflammatory response. 7 / 7
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"Additionally, USP4 overexpression inhibited hepatocyte inflammation and apoptosis on hepatic I/R stimulation."
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"The intervention using Vialinin A and liver X receptor α (LXRα)-induced cannabinoid receptor 2 (CB2) has been found to reduce the level of USP4, leading to alleviate inflammation and fibrosis in the liver (74)."
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"USP4 overexpression antagonized microglia activation-evoked inflammatory response."
35530618
eidos
"In conclusion , USP4 was significantly elevated in autoimmune hepatitis mice and Vialinin A reduced USP4 level and attenuate inflammation and fibrosis in the liver ."
33295107
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"Notably, this study found that reactivating the TRAF6 pathway negated the effects of USP4 on microglial inflammation and subsequent neuron injuries.Collectively, this study highlighted that the USP4 elevation suppressed microglia activation-evoked inflammation and neuron injury by inhibiting the TRAF6-NF-κB pathway."
35530618
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"164 Since FoxP3-driven gene expression patterns can largely determine Treg regulatory function,165 USP4 can lead to impaired Treg cell suppressive function by down-regulating Foxp3, thereby promoting further inflammation development."
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"In conclusion, USP4 was significantly elevated in autoimmune hepatitis mice and Vialinin A reduced USP4 level and attenuate inflammation and fibrosis in the liver."
33295107