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ATXN3 increases the amount of EIF5A2. 4 / 4
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"As shown in Fig. 4 b, the CCK-8 assay data demonstrated that overexpression of EIF5A2 markedly enhanced the proliferation of SW1736 cells, and knockdown of ATXN3 reversed the enhanced proliferation in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, our data indicated that downregulation of ATXN3 expression significantly enhanced the ubiquitination level of EIF5A2, while upregulation of ATXN3 expression showed the opposite effect ( F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, downregulation of ATXN3 promotes sensitivity of neuroblastoma cells to Perifosine and MK-2206, but reduces sensitivity to etoposide and cisplatin in these cells (Gong et al., 2021); ATXN3 enhances breast cancer (BRCA) metastasis by deubiquitinating KLF4 (Zou et al., 2019); ATXN3 promotes mRNA expression of EIF5A2 by stabilizing EIF5A2 to decrease its ubiquitination and degradation in anaplastic thyroid carcinoma (Zhuang et al., 2021)."
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"Our results show that knockdown of ATXN3 decreased EIF5A2 protein expression in 8505c cells without affecting EIF5A2 mRNA levels ( Fig. 3 b, c)."
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