IndraLab

Statements

HSPA activates KCNH2. 8 / 8
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"The cytosolic chaperone proteins Hsp70 and Hsp90 were also discovered to bind to hERG and to mediate maturation of hERG subunits."
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"Furthermore, it is possible that combined manipulation of HSC70, HSP70 and DNAJA1 could enhance their assistance of hERG folding, for at least some of the LQT2 mutants."
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"The reduced expression and inhibition of Hsp90 and Hsp70 will significantly decrease the maturation of the hERG protein and accelerate the degradation of the immature protein (Ficker et al., 2003; Li et al., 2011)."
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"Interestingly, although both Hsp70 and Hsc70 associated with hERG channels, it was reported that Hsp70 enhanced the maturation of hERG channels while Hsc70 suppressed their maturation 59."
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"Expectedly, we found that knockdown of Hsp70 significantly reduced hERG maturation in the presence of FLV (Figure 5G) and LPV (Figure 5H)."
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"Knockdown of Hsp70 reverses drug-induced maturation of the hERG protein."
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"A concern to be addressed will be pleiotropic effects of such therapies - for example, inhibition of HSP70 to relieve CHIP mediated degradation of DeltaF508 CFTR could also impair HSP70 dependent folding of hERG, leading to cardiac arrhythmias in CF patients."
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"XREF_BIBR, XREF_BIBR We have also reported that HSP70 increases the activity of Kv1.5 and hERG channels."
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