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BECN1 binds USP15. 15 / 15
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"USP15 can interact with BECN1 and induce deubiquitination of BCEN1, thereby inhibiting the induction of autophagy (indicated as red dashed arrow)."
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"USP15 interacts with BECN1 and induces deubiquitination of BECN1."
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"Recently, Kim et al. found that USP15 interacted with BECN1 and induced deubiquitination of BECN1, thereby attenuating autophagy induction and negatively regulating lung cancer progression ( xref )."
40438586
biogrid
No evidence text available
35422093
sparser
"Interestingly, USP15 interacted with BECN1 (Fig. xref , lane 4), whereas no significant interaction was observed between USP15 and TRAF6 (Fig. xref , lane 4)."
35422093
biogrid
No evidence text available
35422093
sparser
"To confirm the interaction between USP15 and BECN1 1-127 mutant, IP assay was further performed."
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sparser
"As shown in Fig. xref , FLAG-USP15 interacted with MYC-BECN1 WT and MYC-BECN1 1-127 mutant (Fig. xref , lanes 4 and 5), indicating that USP15 could interact with the N-terminal domain of BECN1 (Fig. xref )."
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sparser
"To further verify the molecular interaction between USP15 and BECN1, we performed a semi-endogenous IP assay because the anti-USP15 antibody used in this study was not suitable for IP assay."
35422093
sparser
"FLAG-USP15 interacted with endogenous BECN1 in the absence of LPS stimulation, and the interaction was significantly enhanced in the presence of LPS stimulation (Fig. xref , lane 4 vs. lane 3), indicating that USP15 interacts with endogenous BECN1."
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sparser
"As depicted in Fig. xref , these results suggest that the molecular association of TRAF6-BECN1 can lead to ubiquitination of BECN1 and induce autophagy induction, whereas the interaction of USP15 with BECN1 can induce the deubiquitination of BECN1 and inhibit autophagy induction."
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sparser
"In addition, biochemical studies revealed that USP15 interacted with BECN1, but not with TRAF6, and induced deubiquitination of BECN1, thereby attenuating autophagy induction."
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sparser
"In the current work, we found that USP15 interacted with BECN1, but not with TRAF6."
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sparser
"The interaction between USP15 and BECN1 led to the deubiquitination of BECN1, resulting in the attenuation of autophagy induction."
35422093
sparser
"We found that USP15 interacted with BECN1, but not with TRAF6, and induced deubiquitination of BECN1."
35422093