IndraLab

Statements

RP binds PRPF8. 4 / 4
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"We further show that a subset of circRNAs were deregulated in the cerebellum of both Prpf8-RP mouse strains."
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"In this study, the use of PRPF8 patient-specific iPSCs provided a genetically matched and physiologically relevant platform for exploring genotype–phenotype correlations in PRPF8-RP."
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"This finding highlights the therapeutic potential of ABE for PRPF8-RP."
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"PRPF8, as a key component of the spliceosome, is crucial for maintaining splicing accuracy and activating the spliceosomal machinery. xref , xref Mutations in the PRPF8 gene cause RP, leading to irreversible vision loss. xref Although recent studies have begun to unravel the specific pathogenic mechanisms of PRPF8-RP, xref the precise role of PRPF8 in spliceosome function and mRNA processing within RPE cells remains poorly understood."
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