IndraLab

Statements

MAP3K7 activates USP18. 3 / 3
| 3
reach
"After TLR ligand stimulation, TAK1 and NEMO undergo K63 linked ubiquitination by TRAF6, while upregulated USP18 targets TAK1 and NEMO."
26240016
reach
"However, NEMO deficiency did not lead to loss of interaction between USP18 and TAK1 (XREF_FIG), suggesting that USP18 targets TAK1 complex and IKK complex by distinct mechanisms."
26240016
reach
"Considering the phenotypes observed with Tak -/- and Usp18 -/- T cells or Usp18 -/- T cells transfected with USP18 (WT) or USP18 (C61S), we further hypothesized that USP18 targets TAK1 complex and catalyzes deubiquitination of TAK1."
23825189