IndraLab

Statements

CYLD inhibits cisplatin. 4 / 4
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"XREF_BIBR Additionally, Sanches et al XREF_BIBR showed that CYLD suppresses cell migration and invasion in cervical cancer, and Suenaga et al XREF_BIBR reported that CYLD downregulates induction of cisplatin resistance in oral squamous cell carcinoma."
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"A previous study reported that CYLD can be regulated by lncRNA CRAL/miR-505 in human gastric cancer cells to reverse cisplatin resistance 59."
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"In addition, loss of CYLD expression causes cisplatin resistance in oral squamous cell carcinoma (OSCC) patients with NF-κB hyperactivation [11]."
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"To test the concept, we conducted both gain- and loss-of-function experiments and found that forced CYLD expression reduced cisplatin resistance by inducing apoptosis and expression of apoptosis-related molecules."
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