IndraLab

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Lithium(1+) inhibits TBK1. 4 / 4
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"Lithium attenuates IFN-beta production and antiviral response via inhibition of TANK binding kinase 1 kinase activity."
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"Lithium has been shown to inhibit TBK1 kinase activity in a GSK3β-independent manner, attenuating TLR3/4 and RIG-I immune pathways that mediate IFNβ production and antiviral responses.39 Thus, lithium was assumed to have therapeutic potential to intervene in autoimmune diseases caused by uncontrolled IFN-β production."
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"In vitro kinase assay demonstrates that lithium suppresses TANK binding kinase 1 kinase activity."
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"Recent report shows that lithium could decrease TANK-Binding Kinase 1 Kinase (TBK-1) activity by competing with Mg 2+ and inhibit the phosphorylation of TBK-1 substrates, which attenuates the IFN-β pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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