IndraLab

Statements

USP11 activates CRC. 11 / 11
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"USP11 promotes CRC progression by stabilizing the protein phosphatase 1 catalytic subunit alpha (PPP1CA) via deubiquitination."
35884607
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"These results indicate that USP11 promotes the progression of CRC by increasing CRC cell proliferation and liver metastasis in vivo.3.4 USP11 may interact with PPP1CA."
31521612
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"To explore how USP11 promotes the progression of CRC, we first transfected HEK293T cells with either Flag–USP11 plasmid or EV plasmid."
31521612
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"Therefore, we hypothesized that USP11 may promote the progression of CRC by stabilizing PPP1CA.To test our hypothesis, we investigated the potential biochemical interrelationship between USP11 and PPP1CA."
31521612
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"USP11 is involved in the development and progression of multiple tumors XREF_BIBR - XREF_BIBR, and we have found that USP11 could promote CRC by stabilizing PPP1CA through deubiquitination XREF_BIBR."
33758608
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"USP11 promoted tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA, suggesting USP11 is a potential prognostic marker."
31521612
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"Our in vitro and in vivo studies demonstrated that USP11 promotes CRC, and the USP11/PPP1CA/MAPK axis plays an important role in CRC progression."
31521612
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"Taken together, our data indicate that USP11 positively regulates the ERK/MAPK signaling pathways in a PPP1CA-dependent manner.3.7 PPP1CA is indispensable for USP11-mediated promotion of CRC."
31521612
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"Sun et al[26] also demonstrated that USP11 promotes the growth and metastasis of CRC via PPP1CA-mediated activation of the ERK/MAPK signaling pathway."
39193162
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"Additionally, USP11 has been shown to enhance the resistance of CRC cells to 5-fluorouracil treatment, suggesting that it may play a role in drug resistance in CRC."
38485957
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"USP11 promotes tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA[66,67]."
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