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KCNMA1 activates calcium(2+). 45 / 45
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"Blockage of the BK channel increased the Ca 2+ current density on the soft substrate and consequently eliminated substrate stiffness regulation of the Ca 2+ channel."
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"These results, together with the aforementioned observation that pharmacological inhibition of the BK channel prevented substrate stiffness regulation of the cardiac L-type Ca 2+ channel, provide cons[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This extremely high positive correlation, together with previous data establishing that LCA-induced dilation of MCA is due to LCA activation of smooth muscle BK channels [ xref ], strongly suggest that the larger LCA-induced BK channel activation in myocytes of BA or CA vs . that of ACA, MCA, PCA or MA, is an important contributor to the larger LCA-induced dilation of the former group of arteries vs . the latter."
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"This is consistent with previous reports that the vasoconstrictor response to 20-HETE is associated with increased TRPC6 and decreased BK channel activities that depolarize the membrane and promote calcium entry through voltage sensitive calcium channels."
28546348
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"We observed that the average intensity of G-CaMP increased over time during GAS infection in an SLO-dependent manner, with the average G-CaMP intensity at 4 h comparable with that in A23187-treated cells (Supplementary Fig. 5a, b) and indicating GAS internalization into the cytosol and/or endosomal membrane damage via SLO-induced cytosolic Ca mobilization."
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"In addition, disruption of the BK Ca gene KCNMA1 which encodes the alpha-subunit of the large conductance Ca 2+ -activated K + channel (BK Ca) led to both haplo-insufficiency and reduced BK Ca activity."
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"Expression of hslo mRNA in Xenopus oocytes produces robust voltage and Ca (2+)-activated K+ currents."
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"Further, our recent findings suggest a decrease in the frequency of Ca 2+ sparks and associated BK channel activity may contribute to enhanced cerebral artery constriction and elevated global cytosolic Ca 2+ (XREF_FIG)."
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"Total alpha-cell Ca 2+ c was similarly reduced (28.3 +/-11.1%) following prolonged treatment with high glucose, but not decreased further by SK or BK channel inhibition."
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"Here, we elucidated the mechanism of Ca 2+ -dependent gating in MthK, a prokaryotic BK channel homologue with a conserved Ca 2+ -dependent gating ring but devoid of voltage sensing domains 5, thus allowing unhampered study of the Ca 2+ -dependent gate."
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"Indeed, in our previous study we showed the BK channel activation by stretch induced Ca 2+ entry via mechanosensitive ion channels whereas no activity of BK currents was observed in physiological range of membrane potentials in the absence of mechanical stimuli 5."
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"If the sensitivity to SLO of the cell type used is unknown, it is important to perform SLO dose response assays using PI as an indicator of cell permeability, to find the optimum SLO concentration that triggers robust calcium dependent lysosomal secretion."
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"SLO and digitonin caused considerable LDH release and calcium independent [3H] dopamine release indicating significant cell membrane and secretory vesicle membrane damage."
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"XREF_BIBR) An encapsulated M3 strain induced apoptosis in human primary keratinocytes triggered by SLO mediated calcium influx and associated with vacuolation of the endoplasmic reticulum and mitochondrial damage."
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"XREF_BIBR investigated the mechanism of NS11021 modulation of BK channels by first recording BK channel currents at various voltages (-240-120 mV), Ca 2+ concentrations (0-100 microM, which saturates Ca 2+ binding), and NS11021 concentrations (0-30 microM)."
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"To investigate the involvement of these Ca dependent kinases in the increase in CREB phosphorylation seen after BK channel inhibition, STO-609, which selectively inhibits Ca and calmodulin-dependent kinase kinase 2 (CaMKK2) which is upstream of CaMKIV [32] and the CaMKII peptide inhibitor, tatCN21 [29], were added to our system.As previously demonstrated in whole cells, BK channel inhibition with paxilline increased CREB phosphorylation sevenfold (**p = 0.0023)."
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"BK channel activation with different rates and durations of Ca 2+ entry."
19897018
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"Mutations in KCNMA1 increase Ca 2+ sensitivity of the channel by three- to five-fold, resulting in generalized epilepsy and paroxysmal dyskinesia [XREF_BIBR]."
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"The BK channel in embryonic chick ventricular myocytes is unique in that, in addition to activation by membrane potential and intracellular Ca 2+, the BK channel can be activated by membrane stretch d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"beta1 was shown to facilitate the gating of BK channels by acting through the Ca 2+ but not the Mg 2+ activating mechanism XREF_BIBR, and the Slo1 tail domains, but not the Ca 2+ bowl were required for beta1 to increase the apparent Ca 2+ sensitivity XREF_BIBR."
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"Although apamin transiently increased Ca 2+ influx into alpha-cells at low glucose (42.9 +/-10.6%), sustained SK (38.5 +/-10.4%) or BK channel inhibition (31.0 +/-11.7%) decreased alpha-cell Ca 2+ influx."
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"SLO induces diverse types of Ca (2+) signalling in host cells which play a key role in membrane repair and cell fate determination."
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"In fact, it has been previously observed that the functional disruption of the calcium bowl does not disrupt BK channel regulation produced by Cd 2+, leading to the suggestion that the BK channel may contain additional Ca 2+ regulatory sites."
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"In this assay, BK channel activity is driven by ionomycin induced calcium influx and is reported by movement of a fluorescent voltage sensitive dye across the cell membrane in response to changes in cell membrane potential."
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"Here, we showed that inhibition of the BK channel abolished substrate stiffness regulation of the cardiac L-type Ca 2+ channel, supporting the idea that the BK channel plays a critical role in substra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We observed a similar Ca 2+ signal when Fluo-3 loaded cells were treated with SLO, another proteinaceous PFT (XREF_FIG)."
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"Physiologically, BK channel activity can be enhanced by elevating cytosolic Ca concentrations, since Ca binds with high affinity to the cytoplasmic domain(s)."
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"A previous study showed that SLO secreted by extracellular GAS induces keratinocyte apoptosis by augmenting calcium influx through transmembrane pores [XREF_BIBR]."
19712038
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"The BK channel can be activated by a depolarizing voltage and increases in intracellular Ca ."
33923953
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"Given the observation that slo-1 (eg142) enhances basal calcium, ACR-16 receptor levels were evaluated in this mutant using the jaSi4 construct."
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"Our results (XREF_FIG and XREF_FIG) reveal that slo mediates the vast majority of all the Ca 2+ -activated K + currents in postembryonic neurons, and that absence of slo induced profound functional compensations from transient voltage gated K + currents, particularly in pupal neurons."
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"These results suggest that NTG, in the therapeutic concentration range, produces coronary relaxation primarily via two cellular mechanisms : plasmalemmal BK channel activation and stimulation of SR Ca (++)-ATPase to produce increased SR Ca+ + accumulation."
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"Secretion of SLO by encapsulated GAS triggers calcium flux into the cytosol of infected cells, leading to vacuolization of the endoplasmic reticulum and cell apoptosis XREF_BIBR."
25165887
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"These data indicate that LRRC26 is an arterial myocyte BK channel auxiliary gamma subunit that elevates voltage- and apparent Ca 2+ -sensitivity to induce vasodilation."
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"Specifically, gliomas express a splice isoform of the channel KCa1.1, which has increased sensitivity to Ca 2+."
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"LRRC26 knockdown did not alter Ca 2+ sparks, but reduced BK channel voltage-sensitivity, which reduced channel apparent Ca 2+ -sensitivity and transient BK current frequency and amplitude in myocytes."
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"We provide evidence that PGE 2 causes : 1) increase in DSM spontaneous phasic contractions in a BK channel dependent manner, 2) elevation of the intracellular Ca 2+ concentration in freshly isolated DSM cells, and 3) inhibition of the amplitude and frequency of TBKCs in freshly isolated DSM cells."
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"The identification of Slo1 gene KCNMA1 and the availability of cDNA of Slo1 for functional expression of BK channels in exogenous cells (Atkinson et al., 1991; Adelman et al., 1992; Butler et al., 1993) allowed the studies to distinguish the distinct Ca and voltage dependent activation mechanisms (Cui et al., 1997)."
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"Reduced BK channel expression leads to impaired Ca 2 + sparks / STOCs coupling , albeit the Ca 2 + spark amplitudes and intracellular Ca 2 + concentrations are known to be elevated in diabetic vascular SMCs ."
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"The mechanisms behind SLO induced Ca (2+) signalling remain poorly understood."
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"LRRC26 knockdown did not alter Ca (2+) sparks but reduced BK channel voltage sensitivity, which decreased channel apparent Ca (2+) sensitivity and transient BK current frequency and amplitude in myocytes."
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"It was proposed that L-type Cav channels, MaxiK channels, CP-AMPARs and calcium induced calcium release (CICR) work in concert within single varicosities to provide an extended range of reciprocal fee[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26772433
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"However, as described by Usmani et al. (101) , the interaction of SLO with the cells could increase the concentration of free Ca 2+ through IP3-mediated depletion of intracellular stores and activation of store-operated Ca 2+ (SOC) entry dependent on the STIM1-Orai1 cross-talk."
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"Later, they found that miR-9 binds to the calcium activated channel subfamily M alpha member 1 (KCNMA1) and negatively regulates its expression."
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"The interactions among VSD, PGD, and CTD are further modulated by BK channel beta subunits, which alter the voltage- and Ca 2+ -dependent activation."
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