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USP14 activates signal transduction. 14 / 14
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"We also found that overexpression of USP14 significantly upregulated β-catenin expression and increased the activity of Wnt/β-catenin signaling pathway."
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"USP14 initiated the NF-kappaB signaling pathway and mediated EMT."
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"USP14 can enhance the signal transduction of Wnt and beta-catenin."
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"In summary, these results substantiated that USP14 initiated the NF-κB signaling pathway to induce EMT and suppress apoptosis (Figure 8)."
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"Another research team discovered that USP14 deubiquitinated K63-linked polyubiquitin chains of Dvl, and USP14 inhibition could attenuate Wnt signal transduction [ 45 ]."
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"Western blots showed that the expression of USP14 positively correlated with the expression of p‐EGFR, EGFR, p‐PI3K, and p‐AKT (Figure 2G), suggesting that USP14 silencing inhibits DDP resistance via the EGFR/PI3K/AKT signaling pathway."
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"Attenuation of Wnt signal transduction by Usp14 inhibition."
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"Increased USP14 promotes mTOR/P70S6K signal transduction, leading to the dedifferentiation of vascular smooth muscle cells (VSMCs), which shift from a quiescent phenotype to a proliferative and migratory phenotype."
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"In addition, USP14 enhances Wnt/β-catenin signaling pathway via stabilizing β-catenin to promote tumor development in lung cancer and hepatocellular cancer (26, 27)."
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"Proteomics analysis revealed that TGT may produce reproductive toxicity by affecting protein digestion and absorption, PPAR signaling pathway, PI3K-Akt signaling pathway, and other pathways."
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"In addition, compared to the normal group, TGT enhanced both the CXCL (Fig. 8I) and CCL (Fig. 8J) signaling pathway networks (Figs."
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"Therefore, TGT may cause reproductive damage by inhibiting the PI3K-Akt signaling pathway."
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"Consistent with expectations, TRAF6 knockdown in USP14 overexpressing macrophages reversed USP14 activation of NF-κB signaling pathway and NLRP3/Caspase-1/IL-1β ( Fig. 7 G and H)."
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"In addition, USP14 and β-catenin are highly correlated in the expression level of HCC, suggesting that high expression of USP14 may enhance Wnt/β-catenin signaling pathway and promote tumor cell proli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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