IndraLab

Statements

USP3 increases the amount of ACSL4. 2 / 2
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"Moreover, USP3 silencing suppressed GSH and GPX4 levels, upregulated iron ion contents, ROS, MDA, and ACSL4 levels, and facilitated ferroptosis."
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"Tao et al. found that ubiquitin-specific protease 3 (USP3) upregulated the expression of the ACOT7 protein through a deubiquitination mechanism, whereas downregulation of USP3 markedly elevated the expression of ACSL4 and promoted ferroptosis in NSCLC cells [71]."
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