IndraLab

Statements

STX1A binds CACNA1B, DPYSL2, and NF1. 4 / 4
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sparser
"Our work also identifies a novel tool–the CRMP2-derived aptamer CNRP, which is capable of uncoupling CRMP2’s interactions with neurofibromin, syntaxin 1A, and Cav2.2."
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sparser
"These results suggest that targeting CRMP2 interactions with neurofibromin, syntaxin 1A and Cav2.2 is beneficial for nociceptive pain behaviors in a rat model of HIV-SN."
28767512
sparser
"We previously found that this peptide inhibited CRMP2’s interaction with CaV2.2, neurofibromin, and syntaxin 1A. A cell-penetrant version of this peptide (t-CNRP1) inhibited CaV2.2 and NaV1.7 currents in Nf1 -edited neurons."
29655575
sparser
"In this platform, neurofibromin interacts with CRMP2 to prevent recruitment of syntaxin 1A and CaV2.2, thus leading to block of CGRP and a reduction in pain behaviors."
29655575