IndraLab

Statements

USP44 activates EZH2. 9 / 9
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"These results demonstrate that USP44 promotes prostate cancer cell tumorigenesis, in part by stabilizing EZH2."
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"Moreover, USP44 knockdown activated EZH2 repressive target genes."
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"In prostate cancer, USP44 promotes disease progression by stabilizing enhancer of zeste homolog 2 (EZH2)."
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"USP44 knockdown activates EZH2 repressive target genes in prostate cancer cells."
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"To characterize the physiological function of the USP44-mediated increase of EZH2 protein stability, we generated USP44 knockdown PC3 and DU145 stable cell lines."
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"Taken together, our results suggest that USP44 promotes the tumorigenesis of prostate cancer cells partly by stabilizing EZH2 and that USP44 is a viable therapeutic target for treating EZH2-dependent cancers."
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"USP44 can induce the genesis of prostate cancer cells partly by stabilizing EZH2 [39]."
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"Furthermore, USP44 promotes the malignancies of prostate cancer cells partly by stabilizing EZH2."
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"USP44 overexpression strongly increased the stability of EZH2 protein compared to the control (Fig. 2C)."
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