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CYLD inhibits signal transduction. 15 / 15
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"Kovalenko et al. have found that CYLD negatively regulated the nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) signaling pathway and identified the interaction between CYLD and NEMO protein [9]."
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"We next sought to define the mechanisms by which SPATA2 and CYLD restrict IFN-γ-STAT1 signal transduction."
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"CYLD is known to suppress the NF-κB signaling pathway during the initial inflammatory response triggered by Escherichia coli, Klebsiella, and Streptococcus pneumoniae, which ultimately exacerbates subsequent lung infections (43–45)."
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"It has been proposed that CYLD inhibits proinflammatory signal transduction [23,35] ."
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"These findings suggest that CYLD can both positively and negatively regulate signal transduction and homeostasis of B cells in vivo, depending on the expression of CYLD splice variants."
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"In this study, we used transgenic mouse and human SCC models to investigate how CYLD loss-of-function leads to abnormal signal transduction and promotes tumorigenesis."
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"Because of abnormal activation of NF-kappaB, CYLD deficiency attenuates the signal transduction of NKT cells stimulated by IL-7."
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"As both CYLD and OTULIN negatively regulate the NF-kappaB signalling cascade, the impact of these deubiquitinases in different LUBAC dependent signalling cascades may be context dependent."
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"CYLD, a member of the deubiquitinating enzyme family, negatively regulates the nuclear factor kappa B (NF-κB) signaling pathway ( Kovalenko et al. 2003, Trompouki et al. 2003 ) and interacts directly [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As a tumor-suppressor gene, CYLD negatively regulates nuclear factor-κB signaling pathway."
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"Conversely, the deubiquitinating enzymes OTULIN (OTU deubiquitinase with linear linkage specificity), A20 (zinc finger protein A20), and CYLD (cylindromatosis) can reverse this signaling pathway, thereby attenuating the expression of downstream molecules (9)."
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"For example, CYLD removes polyubiquitin chains from TBK1 and RIG-I and thus inhibits the IRF3 signaling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances this response (58)."
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"Ectopic expression of CYLD inhibits the IRF3 signalling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances the response."
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"CYLD is a deubiquitination enzyme targeting lysine 63 linked ubiquitin chains and was shown to negatively regulate signal transduction factors and pathways including transforming growth factor-beta and NF-kappaB signaling pathways [XREF_BIBR - XREF_BIBR]."
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"Emerging evidence has suggested that NLRP3 inflammasome activation, which is involved in microglial polarization, requires NF-κB-mediated NLRP3 activation.50–53 In our previous study, we demonstrated that CYLD could negatively regulate the NF-κB signaling pathway."
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