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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TGFB increases the amount of USP15. 2 / 3

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"Monoubiquitination of R-SMADs prevents the R, SMAD, and SMAD4 complex binding with the DNA, while USP15 reverses the modification and promotes TGFbeta dependent transcription."

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"In addition, in the presence of cycloheximide that blocks translation, the levels of USP15 increased by TGF-beta treatments were blocked (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...