IndraLab

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TGFB increases the amount of UCHL1. 6 / 6
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"TGF-β1 did not upregulate UCHL1 expression in these two cell lines (Figure 5a and b), whereas it did induce the expression of CNN1 and inhibited the expression of CDH1 in BEAS-2B cells (Figure 5b)."
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"Wen et al. [24] studies had shown that TGF-β1 could promote PGP9.5 expression in CAFs to enhance colorectal cancer cell proliferation via the ERK1/2 and PI3K signaling pathways."
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"PGP9.5 expression in cultured normal fibroblasts was increased by transforming growth factor beta stimulation, indicating the phenotypic alteration to activated fibroblast."
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"TGF-β can also induce the expression of PGP9.5 [27], enhancing the ability of the eutopic endometrium to invade the myometrium and worsening the degree of dysmenorrhea."
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"Akishima-Fukasawa et al. also found that the expression of both PGP9.5 and α-SMA was increased by TGF-β stimulation and blocked by neutralization of TGF-β with anti-TGF-β antibody [33]."
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"On the other hand, TGF-β can induce the expression of PGP9.5, resulting in nerve fibre invasion into the myometrium and, finally dysmenorrhea.However, this study had some limitations."
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