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OTUB1 binds VCP. 8 / 9
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"Analytical size exclusion chromatography and isothermal titration calorimetry demonstrates that OTU1 can bind VCP in both the presence and absence of a heterodimer formed by ubiquitin fusion degradation protein 1 and nuclear localization protein 4."
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"The activity of Ufd2 is counteracted by the deubiquitylating enzyme Otu1, which binds to Cdc48 and restricts the size of polyubiquitin chains on substrates [116] ."
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"Otu1 and Ufd3 only interact via the chaperone ( Figure 4 H), and, because the two cofactors use different docking sites on the chaperone, Cdc48 can bind Ufd3 and Otu1 at the same time, making a cooper[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Negative staining EM shows that one molecule of OTU1 binds to one VCP hexamer, and isothermal titration calorimetry suggests that the two proteins bind with a KD of 0.71 μM. Analytical size exclusion chromatography and isothermal titration calorimetry demonstrates that OTU1 can bind VCP in both the presence and absence of a heterodimer formed by ubiquitin fusion degradation protein 1 and nuclear localization protein 4."
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"In contrast, the binding of Ufd2 and Otu1 to the same Cdc48 complex is thought to be disfavored ( Rumpf and Jentsch, 2006 ), so that Ufd2 and Otu1 presumably act on distinct conjugates while positione[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we report the structural basis for interaction between VCP and OTU1."
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"Here, we report the structural basis for interaction between VCP and OTU1."
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"In fact, we found also that Otu1 binds Cdc48 via this domain, as a GST-fusion protein that carries only the UBX-like domain of Otu1 bound Cdc48 equally as well as the full-length Otu1 protein (or a mu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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