IndraLab
Statements
reach
"These findings indicate that Usp46, and its allosteric regulators Uaf1 and Wdr20, promote Wingless signaling in target cells in the wing imaginal disc.We further characterized Usp46 mutant cells in the wing disc that were generated by combining CRISPR-based mutagenesis with tissue-specific expression of Cas9 and Usp46 guide RNAs."