IndraLab

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USP14 deubiquitinates CXCR4. 10 / 10
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"Deubiquitination of CXCR4 by USP14 would thus be expected to reduce the rate of ligand accelerated receptor degradation and result in an increased steady state level of receptors."
19106094
signor
"The physical interaction of CXCR4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor|We also observed that ubiquitination of CXCR4 facilitated receptor degradation, whereas overexpression of USP14 or RNAi-induced knockdown of USP14 blocked CXCL12-mediated CXCR4 degradation"
26523394
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"In summary, our findings demonstrate that CXCL12 activation of the CXCR4 leads to a dynamic ubiquitination and deubiquitination cycle and that USP14 preferentially interacts with and deubiquitinates CXCR4."
19106094
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"A previous study showed that USP14 modulates cancer cell motility by deubiquitinating the chemokine receptor CXC chemokine receptor 4 (CXCR4)."
35539036
ubibrowser
"Co-localization of <span class="match term1">CXCR4</span> and <span class="match term0">USP14</span> also is time-dependent following CXCL12 stimulation"
19106094
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"Knockdown of endogenous USP14 blocks CXCR4 deubiquitination and leading to downregulated chemotactic response to CXCL12 [117]."
37658402
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"Mines et al. found that USP14 could induce deubiquitination of CXCR4, thus facilitating its degradation [ 44 ]."
31676235
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"Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12 induced CXCR4 Degradation and Chemotaxis but Not ERK Activation *."
19106094
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"The physical interaction of CXCR4 and USP14 is paralleled by USP14 catalyzed deubiquitination of the receptor; knockdown of endogenous USP14 by RNA interference (RNAi) blocks CXCR4 deubiquitination, whereas overexpression of USP14 promotes CXCR4 deubiquitination."
19106094
reach
"These data suggest that the USP14 gene product indeed serves as a catalyst to deubiquitinate the CXCR4, because when its expression is reduced there is a reciprocal increase in CXCR4 ubiquitination."
19106094