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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Sodium atom activates SCN8A. 2 / 2

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"The identification of this new gain-of-function mutation of Na v 1.6 supports the inclusion of SCN8A as a causative gene in infantile epilepsy, demonstrates a novel mechanism for hyperactivity of Na v 1.6, and further expands the role of de novo mutations in severe epilepsy."

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"This increase in the frequency of SWDs during postnatal development coincides with previously described developmental increases in Na v 1.6 levels (protein product of Scn8a)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...