IndraLab

Statements

USP12 increases the amount of ISG. 3 / 3
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"A previous study has demonstrated that USP12 regulates the IFN/JAK-mediated ISG expression by inhibiting the CBP acetyltransferase activity."
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"However, IFI16 deficiency did not rescue the reduced ISG expression caused by USP12 deficiency (S10A Fig)."
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"Moreover, USP12 overexpression upregulated ISG (ISG15, MX1, and IFIT1) expression (S5C and S5D Fig) and significantly inhibited HSV-1 and VSV replication, as indicated by the RNA levels (S5E Fig) and viral titers (S5F Fig)."
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