IndraLab

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USP22 deubiquitinates HES1. 3 / 3
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"Another study demonstrated that USP27x, Usp22, and Usp51 deubiquitinate and stabilize Hes1 protein, a transcriptional repressor necessary for the maintenance of neural stem/progenitor cells."

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"Hes1, which undergoes a fast turnover rate due to its degradation by the proteasome, is deubiquitinated and stabilized by USP22 [102]."

"A recent study showed that <span class="match term0">USP22</span>- mediated deubiquitination of Hairy and Enhancer of split 1 (<span class="match term1">Hes1</span>) is important for neuronal differentiation in the developing brain"