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PRKAA1 inhibits KCNA5. 2 / 6

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"Inhibition of mitochondrial oxidative phosphorylation with either phenformin or hypoxia was found to result in AMP-activated protein kinase (AMPK)-mediated inhibition of Kv1.5 channels in rat PASMCs."

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"Thus, it has been shown that AMPKα1 activation induced by LKB1 inhibits Kv1.5 channel currents in PASMCs and leads to pulmonary vasoconstriction in response to moderate and severe hypoxia [117,153]."

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Statements

PRKAA1 inhibits KCNA5. 2 / 6

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