IndraLab

Statements

USP7 activates autophagy. 8 / 8
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"36 Of note, our data revealed that inhibition of proteasome up-regulated expression of USP7 and KDM6B, while increased USP7 expression promoted osteoblast differentiation and autophagy, alleviating osteoporosis."
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"Mechanistically, miR-15 bound and inhibited USP7 expression, while overexpression of USP7 promoted autophagy of osteoblasts."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"Therefore, the obtained data suggested that USP7 could induce osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
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"3.5 USP7 promoted osteoblast differentiation and autophagy to ameliorate osteoporosis by increasing KDM6B expression."
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"43 In conclusion , our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7 , which potentially suppress the osteoblast proliferation , differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression ( Figure 7 ) ."
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"36 Of note , our data revealed that inhibition of proteasome up-regulated expression of USP7 and KDM6B , while increased USP7 expression promoted osteoblast differentiation and autophagy , alleviating osteoporosis ."
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"Thus, these findings support that restoration of USP7 underlies the anti-osteogenic effect of miR-15b by stimulating osteoblast proliferation, differentiation, and autophagy."
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