IndraLab

Statements

Modified HSP90beta increases the amount of KCNQ4. 5 / 5
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"Cell surface expression of the KCNQ4 channel in HEK293T cells mimicking heterozygous conditions of two DFNA2 mutations, L274H and W276S, could be restored by overexpression of HSP90beta XREF_BIBR."
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"Then, we tested whether cell surface expression of the KCNQ4 channel could be restored by HSP90beta overexpression in HEK293T cells mimicking the heterozygous condition of DFNA2 patients."
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"Overexpression of HSP90beta increased cell surface expression of the WT KCNQ4 channel by 26 +/- 10.93% (XREF_FIG A)."
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"Over-expression of HSP90beta significantly increased surface expression of WT KCNQ4 channels (26 +/- 10.93%), while over-expression of HSP40 and HSP70 had no effect (XREF_FIG)."
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"In both cases, Western blot showed that KCNQ4 surface expression could be restored to the WT level by HSP90beta over-expression (XREF_FIG)."
23431407