IndraLab

Statements

IL15 activates IL2RG. 7 / 7
1 | 6
reach
"Since IL-15 and IL-2 stimulate signaling via the same receptor subunits, IL-2 and IL-15b and common gamma chain (gammac) 26, we wondered whether Tbkbp1 also played a role in regulating IL-2-stimulated signaling in NKT cells."
30022064
reach
"Moreover, although MFI value of pSTAT-1 in IL-15 stimulated, gammac receptor neutralized PBMCs (green line) was reduced in comparison with IL-15 stimulated normal PBMCs (P = 0.0027, Figure XREF_FIG), it is still remarkably elevated in comparison of MFI value in gammac receptor neutralized PBMCs (P < 0.0001, Figure XREF_FIG)."
28401068
reach
"Similarly, IL-15 also signals through a heterotrimeric receptor, consisting of the shared subunits (CD122 and the gamma c) and the unique high affinity receptor, IL-15Ralpha (CD215)."
31816491
reach
"JAK3 is solely activated by type I cytokine receptors featuring a common gamma-chain (gammac) subunit that are activated by IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 7; mutations in either the gamma-chain or JAK3 have been identified in humans as a cause of severe combined immunodeficiency disease (SCID), which manifests as a depletion of T, B, and natural killer (NK) cells with no other defects XREF_BIBR, XREF_BIBR."
29588471
signor
"The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex."
11418623
reach
"IL-15 induces signaling by both cis- and trans-presentation of IL-15 and IL-15Ralpha to CD122 and gammac."
21984699
reach
"Our results suggest the existence in both normal and leukemic CD34+ cells of a constitutive production of a bioactive IL-15 that does not lead to NK differentiation and further indicate that membrane bound IL-15 and constitutive activation of gammac are hallmarks of leukemic progenitors."
10851076