IndraLab

Statements


PCNA inhibits USP1. 2 / 2
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"USP1 dependent PCNA deubiquitylation is regulated, on one hand, by UV irradiation dependent inactivation of USP1 through an autocleavage event and, on the other hand, by the PCNA interacting ELG1 protein that is essential for recruiting USP1-UAF1 to the stalled fork."

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"(2) PCNA deubiquitination to limit the DNA damage bypass pathway by recruiting the USP1 and USP1 associated factor 1 (UAF1) complex [XREF_BIBR]."