IndraLab

Statements

USP15 inhibits SQSTM1. 2 / 2
1 | 1
reach
"Indeed, overexpression of wild-type USP15 dramatically decreased short-chain modification of SQSTM1 with ubiquitin in a manner dependent on its catalytic Cys 269 residue (XREF_FIG A and 6B)."
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signor
"SQSTM1 Is a Substrate for RNF26 and the DUB USP15. Catalytically competent RNF26 (light red) recruits SQSTM1 (blue) and mediates ubiquitin ligation (red), which serves to attract UBDs of specific vesicle-associated adaptors. Dissociation of the RNF26/SQSTM1 complex, promoted by the DUB USP15 (yellow), releases target vesicles for (4) fast transport into the cell periphery."
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