IndraLab

Statements

USP2 inhibits IL22. 3 / 3
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"Knockout or pharmacologic inhibition of USP2 promotes the proliferation of myeloid cells to activate IL-22 and IFNgamma production of T cells."
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"These data together suggest that inhibition of USP2 promotes the proliferation of macrophages and dendritic cells to activate IL-22- and IFNγ-producing T cells during DSS-induced colitis.We also examined whether targeting USP2 by ML364 inhibited the dysregulation of ECM and promoted tissue repair."
37192862
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"Taken together, these data suggest that USP2 restricts the proliferation of myeloid cells and thereby inhibits the activation and expansion of IL-22- and IFNγ-producing T cells in the lamina propria during DSS-induced colitis.2.6 USP2 in myeloid cells inhibits immune responses to bacterial infections in the gut."
37192862