IndraLab

Statements

Simvastatin inhibits RELA. 8 / 9
1 | 8
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"Simvastatin Reduces RelA and Transiently Increases c-Rel in the Nuclear Fraction of pMCAO Rats."
37204689
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"Neither quinapril nor simvastatin given for 7 d produced a suppression of ROS generation, intranuclear NF-kappa B, p65, or CRP, and these two agents did not alter cellular I kappa B either."
12970329
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"As shown in Fig. 2 C, p65 protein turnover increased in simvastatin-treated cells, suggesting a role for protein stabilization in simvastatin-induced p65 down-regulation."
25316568
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"However, knock-down of SOCS1 abolished simvastatin-induced p65 degradation in the cell nucleus."
25316568
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"Simvastatin alone or together with amfenac significantly reduced the DNA binding of NF-κB p65 whereas amfenac had no effect (Fig. 3a)."
38530532
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"Simvastatin therapy also significantly reduced monocytic nuclear factor-kappaB p65 activity, compared with placebo (P < 0.01)."
17519305
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"The findings that simvastatin-induced p65 down-regulation further reduces MMP-2 expression in SP600125-treated ( Fig. 4 D), c-Jun/ATF-2 siRNA-transfected ( Fig. 4 E) and JNK1 shRNA-transfected ( Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25316568
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"In a previous study, it was reported that simvastatin reduced the nucleolar content of the NFκB-RelA complex while increasing NFκB-cRel combination."
38930515