IndraLab

Statements

RNAi inhibits USP8. 2 / 2
| 2
reach
"We sought to understand the mechanism by which Hh reduces Smo ubiquitination and found that the inactivation of USP8 by RNAi or by the expression of a dominant negative USP8 abolished the effects of Hh on Smo ubiquitination."
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reach
"We also found that inactivation of USP8 by RNAi or by USP8C> S overexpression caused an enlargement of the early endosome (XREF_FIG and XREF_FIG), which was consistent with a previous finding that USP8 deficient mouse primary cells exhibit enlarged early endosomes XREF_BIBR."
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